Synthesis and structure-activity relationships of 2-azetidinone-1-sulfonic acid derivatives with a heteroatom-bound substituent at the 4-position.

Abstract

The synthesis and antibacterial activity of 3-[(Z)-2-alkoxyimino-2-(2-aminothiazol-4-yl)-acetamido] -2-azetidinone-1-sulfonic acid derivatives with a heteroatom-bound substituent at the 4-position are described. The effect of various 4-substituents on the antibacterial activity was examined. Some of these compounds showed excellent antibacterial activity… (More)

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@article{Noguchi1985SynthesisAS, title={Synthesis and structure-activity relationships of 2-azetidinone-1-sulfonic acid derivatives with a heteroatom-bound substituent at the 4-position.}, author={Norihisa Noguchi and H Masuya and Taku Sugawara and Y. Kawano and Toshihiko Matsuo and Masako Ochiai}, journal={The Journal of antibiotics}, year={1985}, volume={38 10}, pages={1387-400} }