Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities.

@article{Moon2006SynthesisAS,
  title={Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities.},
  author={Myoung Ju Moon and Sang Kook Lee and Jong Won Lee and Woo Keun Song and Si W Kim and Jae Il Kim and Chunghee Cho and Soo Jeong Choi and Yong-Chul Kim},
  journal={Bioorganic & medicinal chemistry},
  year={2006},
  volume={14 1},
  pages={237-46}
}
Indirubin, an active ingredient of a traditional Chinese recipe Danggui Longhui Wan, has been known as a CDK inhibitor competing with ATP for binding to the catalytic site of cyclin-dependent kinases (CDKs). Since CDKs, a group of serine/threonine kinases forming active heterodimeric complexes with cyclins, are key regulators of the cell cycle regulation, therapeutic interventions targeting CDKs have been stimulated for the treatment of proliferative diseases, such as cancer, psoriasis, and for… CONTINUE READING
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