Synthesis and structure-activity relationships of novel warfarin derivatives.

  title={Synthesis and structure-activity relationships of novel warfarin derivatives.},
  author={Markus G Gebauer},
  journal={Bioorganic & medicinal chemistry},
  volume={15 6},
4-Hydroxycoumarins such as warfarin 1 have been the mainstay of oral anticoagulation therapy for over 20 years. Yet little detail is known about the molecular interactions between 4-hydroxycoumarins with vitamin K epoxide reductase (VKER), inhibition of which produces a deficiency of vitamin K and consequently a deficiency of vitamin K-dependent proteins involved in thrombus formation. Using molecular probes, such as 4-sulfhydrylwarfarin 7 and 4-chlorowarfarin 10 it is shown in vitro that… CONTINUE READING


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