Synthesis and structure-activity relationship effects on the tumor avidity of radioiodinated phospholipid ether analogues.

@article{Pinchuk2006SynthesisAS,
  title={Synthesis and structure-activity relationship effects on the tumor avidity of radioiodinated phospholipid ether analogues.},
  author={A. Pinchuk and M. A. Rampy and M. Longino and R. Skinner and M. Gross and J. Weichert and R. Counsell},
  journal={Journal of medicinal chemistry},
  year={2006},
  volume={49 7},
  pages={
          2155-65
        }
}
Radioiodinated phospholipid ether analogues have shown a remarkable ability to selectively accumulate in a variety of human and animal tumors in xenograft and spontaneous tumor rodent models. It is believed that this tumor avidity arises as a consequence of metabolic differences between tumor and corresponding normal tissues. The results of this study indicate that one factor in the tumor retention of these compounds in tumors is the length of the alkyl chain that determines their hydrophobic… Expand
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