Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists.

Abstract

A series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT(1) and MT(2) receptors was determined using 2-[(125)I]-iodomelatonin as the radioligand. From this series of benzoxazole derivatives, compounds 14 and 17 were identified as melatonin receptor agonists.

Cite this paper

@article{Sun2004SynthesisAS, title={Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists.}, author={Li-Qiang Sun and Jie Chen and Marc A Bruce and Jeffrey A Deskus and James R Epperson and Katherine S Takaki and Graham Johnson and Lawrence G. Iben and Cathy D. Mahle and Elaine A. Ryan and Cen Xu}, journal={Bioorganic & medicinal chemistry letters}, year={2004}, volume={14 14}, pages={3799-802} }