Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.

@article{Belema2007SynthesisAS,
  title={Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.},
  author={Makonen Belema and Amy Bunker and Van Nhien Albert Nguyen and Francis Beaulieu and Carl Ouellet and Yuping Qiu and Yunhui Zhang and Alain Martel and James R Burke and Kim W Mcintyre and Mark A. Pattoli and Connie Daloisio and Kathleen M. Gillooly and Wendy J Clarke and Patrick J. Brassil and F Chris Zusi and D. M. Vyas},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 15},
  pages={4284-9}
}
The identification of a potent series of IKK-beta selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog (22j) in the LPS-induced TNF-alpha release mouse model are described. 

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