Synthesis and structural studies of asparagine-modified 2-deoxy-alpha-N-glycopeptides associated with the renin-angiotensin system.

Abstract

Following addition of N-iodosuccinimide to glycals, reductive hydrogenolysis and ring opening gave 2-deoxy-alpha-N-glycopeptides carrying a deaminated asparagine unit. This reaction could be performed employing glucal, galactal, L-rhamnal, L-fucal and lactal to give the corresponding glycoconjugate building blocks 11, 12, 17, 22, 27 and 32. Further NIS… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics