Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3‐chloro‐4‐hydroxyphenylacetamide

@article{Davis2007SynthesisAS,
  title={Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3‐chloro‐4‐hydroxyphenylacetamide},
  author={R. Davis and G. Pierens and P. G. Parsons},
  journal={Magnetic Resonance in Chemistry},
  year={2007},
  volume={45}
}
  • R. Davis, G. Pierens, P. G. Parsons
  • Published 2007
  • Chemistry, Medicine
  • Magnetic Resonance in Chemistry
  • Parallel solution‐phase chemistry has yielded a series of secondary amide analogues of the fungal natural product 3‐chloro‐4‐hydroxyphenylacetamide. 3‐Chloro‐4‐hydroxyphenylacetic acid was coupled to a variety of primary amines using 1‐ethyl‐3‐(3′‐dimethylamino‐ propyl)‐carbodiimide hydrochloride. The desired products were obtained in good yield and high purity following rapid silica purification. All analogues were spectroscopically characterised using NMR, UV, IR and MS data. One compound… CONTINUE READING
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