Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3‐chloro‐4‐hydroxyphenylacetamide

@article{Davis2007SynthesisAS,
  title={Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3‐chloro‐4‐hydroxyphenylacetamide},
  author={R. Davis and G. Pierens and P. G. Parsons},
  journal={Magnetic Resonance in Chemistry},
  year={2007},
  volume={45}
}
  • R. Davis, G. Pierens, P. G. Parsons
  • Published 2007
  • Chemistry, Medicine
  • Magnetic Resonance in Chemistry
    • Parallel solution‐phase chemistry has yielded a series of secondary amide analogues of the fungal natural product 3‐chloro‐4‐hydroxyphenylacetamide. 3‐Chloro‐4‐hydroxyphenylacetic acid was coupled to a variety of primary amines using 1‐ethyl‐3‐(3′‐dimethylamino‐ propyl)‐carbodiimide hydrochloride. The desired products were obtained in good yield and high purity following rapid silica purification. All analogues were spectroscopically characterised using NMR, UV, IR and MS data. One compound… CONTINUE READING
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    15 Citations
    Background Citations
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    Methods Citations
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    15 Citations
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    References

    SHOWING 1-10 OF 18 REFERENCES
    Synthesis and Biological Evaluation of a Focused Mixture Library of Analogues of the Antimitotic Marine Natural Product Curacin A
    • 66
    Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid: a novel scaffold for combinatorial synthesis of coumarins.
    • 19
    Screening a natural product-based combinatorial library using FTICR mass spectrometry.
    • 27
    • PDF
    The isolation and synthesis of 3-chloro-4-hydroxy-phenylacetamide produced by a plant-associated microfungus of the genus Xylaria
    • 22
    • PDF
    The Synthesis of a Combinatorial Library Using a Tambjamine Natural Product Template
    • 24
    Natural products as scaffolds for chemical diversification: solution-phase parallel synthesis of a series of naringin analogues.
    • 6
    Solution-phase synthesis of a thiazoyl-substituted indolyl library via Suzuki cross-coupling.
    • 17
    SOLID AND SOLUTION PHASE SYNTHESIS AND BIOLOGICAL EVALUATION OF COMBINATORIAL SARCODICTYIN LIBRARIES
    • 98
    Solution phase synthesis of libraries of polycyclic natural product analogues by cascade radical annulation: synthesis of a 64-member library of mappicine analogues and a 48-member library of mappicine ketone analogues.
    • 19
    Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries.
    • 218