Synthesis and solid state conformation of phenylalanine mimetics constrained in a proline-like conformation.

@article{Gardiner2004SynthesisAS,
  title={Synthesis and solid state conformation of phenylalanine mimetics constrained in a proline-like conformation.},
  author={James Gardiner and Andrew D. Abell},
  journal={Organic & biomolecular chemistry},
  year={2004},
  volume={2 16},
  pages={2365-70}
}
We present the synthesis of five- and six-membered cyclic phenylalanine mimics (1, 9, 16 and 17) that are constrained in a proline-like conformation. The five-membered mimetic 16 was prepared by Ring Closing Metathesis (RCM) of diene 15, itself prepared by alpha-benzylation of the L-methionine derived oxazolidinone 10, followed by oxidative elimination… CONTINUE READING