Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones.


Ribonucleotide reductase (RR) is an important therapeutic target for anticancer drugs. The structure of human RR features a 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2. Prokaryotically expressed and highly purified recombinant human RR subunits, hRRM1 and hRRM2, were used for holoenzyme-based [(3)H]CDP reduction in vitro assay. Ten new… (More)
DOI: 10.1016/j.bmcl.2008.09.097


3 Figures and Tables