Synthesis and restriction enzyme analysis of oligodeoxyribonucleotides containing the anti-cancer drug 2',2'-difluoro-2'-deoxycytidine.

@article{Richardson1992SynthesisAR,
  title={Synthesis and restriction enzyme analysis of oligodeoxyribonucleotides containing the anti-cancer drug 2',2'-difluoro-2'-deoxycytidine.},
  author={Frank C. Richardson and Katherine K. Richardson and Julian S. Kroin and Lary W Hertel},
  journal={Nucleic acids research},
  year={1992},
  volume={20 7},
  pages={1763-8}
}
The anti-cancer drug 2',2'-difluoro-2'-deoxycytidine (dFdC) is internally incorporated into DNA in vitro. To determine the effects of this incorporation on DNA structure and function, the beta-cyanoethyl phosphoramidite of dFdC was synthesized and oligodeoxyribonucleotides containing dFdC were made using automated solid phase DNA synthesis techniques… CONTINUE READING