Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes.

@article{Koga1992SynthesisAR,
  title={Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes.},
  author={Shin Koga and Satoshi Ogawa and Koichiro Kuwabara and Jonathan Brett and Justine Leavy and Joanne L Ryan and Y Fujioka Koga and J M Plocinski and W S Benjamin and Dennis K. Burns},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 3},
  pages={1007-15}
}
To examine the possible involvement of cytokines in reperfusion injury, we have studied production of IL-1 by human vascular cells, including smooth muscle and mononuclear phagocytes. Exposure of cells to hypoxia (pO2 approximately 14 torr) followed by reoxygenation led to significant release of IL-1 only from the mononuclear phagocytes. Elaboration of IL-1 was dependent on the oxygen tension and duration of hypoxia (optimal at lower pO2s, approximately 14-20 torr, and after 9 h), as well as… CONTINUE READING