Synthesis and regulation of keratinocyte collagenase.

  title={Synthesis and regulation of keratinocyte collagenase.},
  author={Marta Jean Petersen and David T. Woodley and George P Stricklin and Edward J O'Keefe},
  journal={Matrix (Stuttgart, Germany). Supplement},
We have recently demonstrated that human keratinocytes synthesize and secrete procollagenase and tissue inhibitor of metalloproteinases (TIMP) in culture. We have examined the response of keratinocyte collagenase production to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), interleukin-1, extracellular matrix proteins and phagocytosis. Collagenase production in keratinocytes was markedly stimulated by TPA and paralleled the morphologic changes induced by the phorbol ester… CONTINUE READING

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