Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.

@article{Zhang2000SynthesisAR,
  title={Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.},
  author={Fagen Zhang and Peter Wei-Jen Fan and Xuemei Liu and Liduo Shen and Richard B van Breemen and Judy L Bolton},
  journal={Chemical research in toxicology},
  year={2000},
  volume={13 1},
  pages={53-62}
}
Although tamoxifen is approved for the treatment of hormone-dependent breast cancer as well as for the prevention of breast cancer in high-risk women, several studies in animal models have shown that tamoxifen is heptocarcinogenic, and in humans, tamoxifen has been associated with an increased risk of endometrial cancer. One potential mechanism of tamoxifen carcinogenesis could involve metabolism of tamoxifen to 3,4-dihydroxytamoxifen followed by oxidation to a highly reactive o-quinone which… CONTINUE READING

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