Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D2 dopamine receptor agonist

@article{Horn2006SynthesisAR,
  title={Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D2 dopamine receptor agonist},
  author={Alan S. Horn and Pieter G. Tepper and Jan van der Weide and M. Watanabe and Dimitri E. Grigoriadis and Philip Seeman},
  journal={Pharmaceutisch Weekblad},
  year={2006},
  volume={7},
  pages={208-211}
}
The synthesis of a new, potent and selective D2 dopamine receptor agonist, N-0437, of the 2-aminotetralin group is described. The results of a radioreceptor binding assay using a homogenate of porcine anterior pituitary as a tissue source for D2 dopamine receptors and3H-spiperone as radioligand demonstrate that this compound is one of the most potent compounds so far evaluated in this test system. 
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