Synthesis and radiation-protection and antihypoxia properties of 3-hydroxypiperidin-4-one derivatives

@article{Ilyuchenok2004SynthesisAR,
  title={Synthesis and radiation-protection and antihypoxia properties of 3-hydroxypiperidin-4-one derivatives},
  author={T. Yu. Il'yuchenok and M. N. Romanchak and I. G. Tishchenko and L. S. Stanishevskii and L. M. Frigidova and Yu. V. Zav'yalov and K. S. Shadurskii and A. S. Zakharevskii and A. V. Miklevich},
  journal={Pharmaceutical Chemistry Journal},
  year={2004},
  volume={12},
  pages={219-221}
}
Cinnamoyl oxiranes (Ia-h) are condensed by known methods with methyland benzylamines to give the C(3)-stereoisomeric, 6-aryl-substi tuted 3e-hydroxypiperidin-4-ones (II-IX) [2] and 3a-hydroxypiperidin-4-ones (X-XIV) [3] (see Table 1). Their physical constants and spectral data correspond with l i terature values [2, 3]. Thus, the PMR spectra for the compounds exhibit a signal for protons of the C-3 methyl group in the interval 1.50-1.55 ppm, which corresponds to their axial orientation [3].