Synthesis and radiation dosimetry of 4-borono-2-[18F]fluoro-D,L-phenylalanine: a target compound for PET and boron neutron capture therapy.

@article{Ishiwata1991SynthesisAR,
  title={Synthesis and radiation dosimetry of 4-borono-2-[18F]fluoro-D,L-phenylalanine: a target compound for PET and boron neutron capture therapy.},
  author={Kiichi Ishiwata and Tatsuo Ido and Alfonso Alonso Mejia and Masamitsu Ichihashi and Yuko Mishima},
  journal={International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes},
  year={1991},
  volume={42 4},
  pages={325-8}
}
The 18F-labeling of 4-borono-D-L-phenylalanine (BPA), a potential target compound for cancer treatment with boron neutron capture therapy, is described. By direct fluorination of BPA with [18F]AcOF or [18F]F2 followed by HPLC separation, 4-borono-2-[18F]fluoro-D,L-phenylalanine was prepared with radiochemical yields of 25-35% and with a radiochemical purity of over 99%. The tissue distribution study showed that the compound has potential as a tracer for pancreas imaging with positron emission… CONTINUE READING