Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides.

@article{Ford1986SynthesisAQ,
  title={Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides.},
  author={R. Ford and P. Knowles and E. Lunt and S. Marshall and A. Penrose and C. Ramsden and A. J. Summers and J. L. Walker and D. Wright},
  journal={Journal of medicinal chemistry},
  year={1986},
  volume={29 4},
  pages={
          538-49
        }
}
  • R. Ford, P. Knowles, +6 authors D. Wright
  • Published 1986
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • The synthesis and antiallergic activity of a series of 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and isomeric N-(2-hydroxyphenyl)-1H-tetrazole-5-carboxamides is described. A relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test has been established using a Hansch/Free-Wilson model and used to direct studies toward potent derivatives. The contribution of physicochemical properties to activity is discussed. One member of this series… CONTINUE READING
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