Synthesis and properties of oligonucleotides containing 2'-deoxynebularine and 2'-deoxyxanthosine.

@article{Eritja1986SynthesisAP,
  title={Synthesis and properties of oligonucleotides containing 2'-deoxynebularine and 2'-deoxyxanthosine.},
  author={R. Eritja and D. Horowitz and P. Walker and J. Ziehler-Martin and M. Boosalis and M. Goodman and K. Itakura and B. Kaplan},
  journal={Nucleic acids research},
  year={1986},
  volume={14 20},
  pages={
          8135-53
        }
}
The preparation of synthetic oligonucleotides containing 2'-deoxynebularine (dN) and 2'-deoxyxanthosine (dX) is described. The thermal stabilities of duplexes containing dX, dN, and 2'-deoxyinosine (dI) base-paired with the four natural bases have been measured. Xanthine base pairs have stabilities at pH 5.5 that are similar to those of dI-containing duplexes at neutral pH. When xanthine is paired with adenine or cytosine an unusual stabilization of the duplex structure is observed at acid pH… Expand
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