Synthesis and properties of 7-substituted 7-deazapurine (pyrrolo[2,3-d]pyrimidine) 2'-deoxyribonucleosides.


7-Substituted 7-deazapurine (pyrrolo[2,3-d]pyrimidine) 2'-deoxyribonucleosides are synthesized by stereoselective nucleobase anion glycosylation. The introduction of a halogen at C7 is performed regioselectively either on the nucleobase or on the nucleoside. The pK(a) values of a series of 7-deazapurine 2'-deoxyribonucleosides are provided, and fluorescence properties are also discussed.

DOI: 10.1002/0471142700.nc0110s21

Cite this paper

@article{Seela2005SynthesisAP, title={Synthesis and properties of 7-substituted 7-deazapurine (pyrrolo[2,3-d]pyrimidine) 2'-deoxyribonucleosides.}, author={Frank Seela and Xiaohua Peng}, journal={Current protocols in nucleic acid chemistry}, year={2005}, volume={Chapter 1}, pages={Unit 1.10} }