Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents.

  title={Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents.},
  author={Marcus Adrian Cheek and Mikhail I. Dobrikov and Charlotta K. Wennefors and Zhihong Xu and S. A. Nadeem Hashmi and Xiaoying Shen and Barbara Ramsay Shaw},
  journal={Nucleic acids symposium series},
The alpha-P-borano modification, where one of the alpha-phosphate oxygens is replaced by borane, of chain terminating nucleoside triphosphates are currently being tested in cell culture and are showing promise as effective viral polymerase inhibitors. The goal of this project is to combine the alpha-P-borano and Nanogel drug delivery technology to increase the antiviral potency of chain terminating sugar and base modified purine nucleosides versus the Hepatitis C Viral RNA dependent RNA… 
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