Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents.

@article{Cheek2008SynthesisAP,
  title={Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents.},
  author={Marcus Adrian Cheek and Mikhail I. Dobrikov and Charlotta K. Wennefors and Zhihong Xu and S. A. Nadeem Hashmi and Xiaoying Shen and Barbara Ramsay Shaw},
  journal={Nucleic acids symposium series},
  year={2008},
  volume={52},
  pages={
          81-2
        }
}
The alpha-P-borano modification, where one of the alpha-phosphate oxygens is replaced by borane, of chain terminating nucleoside triphosphates are currently being tested in cell culture and are showing promise as effective viral polymerase inhibitors. The goal of this project is to combine the alpha-P-borano and Nanogel drug delivery technology to increase the antiviral potency of chain terminating sugar and base modified purine nucleosides versus the Hepatitis C Viral RNA dependent RNA… 
Protection-free one-pot synthesis of 2'-deoxynucleoside 5'-triphosphates and DNA polymerization.
TLDR
A one-pot synthesis of deoxyribonucleoside 5'-triphosphates without any protection on the nucleosides is designed and developed by generating an in situ phosphitylating reagent that reacts selectively with the 5'-hydroxyl groups of the unprotected nucleoside.
Convenient synthesis of nucleoside 5′-(α-P-thio)triphosphates and phosphorothioate nucleic acids (DNA and RNA)
TLDR
This facile synthesis is achieved by treating the nucleosides with a mild phosphitylating reagent, reacting selectively with the 5′-hydroxyl group of each unprotected nucleoside, followed by sulfurization and hydrolysis to afford the crude dNTP αS and NTPαS analogs (mixtures of Sp and Rp diastereomers).
Convenient synthesis of nucleoside 5'-triphosphates for RNA transcription.
TLDR
By generating a selective phosphitylating reagent in situ, nucleoside 5'-triphosphates can be conveniently synthesized in one pot to largely simplify synthesis of the nucleosid triphosphate synthesis of both native and modified nucleosides.
Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch
TLDR
The synthesis and biophysical studies of a series of c-di-GMP analogues, which have both phosphate and sugar moieties simultaneously modified (called endo-S-c- di-G MP analogues), and computational methods to predict the relative orientation of the guanine nucleobases in c-Di-Gmp and analogues are reported.
Use of a Novel 5′‐Regioselective Phosphitylating Reagent for One‐Pot Synthesis of Nucleoside 5′‐Triphosphates from Unprotected Nucleosides
TLDR
This unit presents a protocol for convenient synthesis of 2′‐deoxyribo‐ and ribonucleoside 5′‐triphosphates (dNTPs and NTPs) from any natural or modified base.
Boron-containing compounds: chemico-biological properties and expanding medicinal potential in prevention, diagnosis and therapy
TLDR
Although uncertainties exist about the mechanism of action of BCCs, increasing evidence about their toxicological profile strongly suggests that many can be safely administered to humans, and it seems fair to say that some BCCs will reach the market for medicinal use in the near future.
A Systematic Review of the Biological Effects of Cordycepin
TLDR
It is concluded that cordycepin has excellent potential as a lead for drug development, especially for age-related diseases, and the remaining issues around the mechanism of action, toxicity and biodistribution of cordYcepin are discussed.
Nucleic Acids as Biomolecular Probes: Synthesis, Substrate, and Antiviral Properties
TLDR
The α-P-borano modification can be used to probe the catalytic phosphoryl transfer mechanism used by viral polymerases, and possibly enhance existing anti-viral chain terminating nucleotides.