Synthesis and preliminary in vitro cytotoxic activity of novel cisplatin and carboplatin analogues.

Abstract

Six new platinum(II) complexes were synthesized from a common triphenylethylene precursor using various diamines. The cytotoxicity of the compounds, evaluated on human breast cancer cell lines (MCF-7 and MDA-MB-231), was greatly influenced by the nature of the diamine ligand. Two derivatives presented cytotoxic activity greater than tamoxifen and, for the… (More)

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Cite this paper

@article{Sene1998SynthesisAP, title={Synthesis and preliminary in vitro cytotoxic activity of novel cisplatin and carboplatin analogues.}, author={A. Sene and G. Roger B{\'e}rub{\'e} and R. C. Gaudreault}, journal={Drug design and discovery}, year={1998}, volume={15 4}, pages={277-85} }