Synthesis and preliminary evaluation of 3-thiocyanato-1H-indoles as potential anticancer agents.


A novel series of twenty 3-thiocyanato-1H-indoles, carrying diversification at positions N-1, C-2 and C-5 of the heterocyclic core, were synthesized; their antiproliferative activity against four human cancer cell lines (HL60, HEP-2, NCI-H292 and MCF-7) was evaluated, employing doxorubicin as positive control. Indole, N-methylindole and 2-(4-chlorophenyl)-N… (More)
DOI: 10.1016/j.ejmech.2016.04.039


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