Synthesis and preclinical evaluation of an 18F labeled PDE7 inhibitor for PET neuroimaging.

@article{Thomae2015SynthesisAP,
  title={Synthesis and preclinical evaluation of an 18F labeled PDE7 inhibitor for PET neuroimaging.},
  author={David Thomae and Stijn Servaes and Naiara V{\'a}zquez and Leonie Wyffels and Stefanie Dedeurwaerdere and Pieter van der Veken and Jurgen Joossens and Koen Augustyns and Sigrid Stroobants and Steven Staelens},
  journal={Nuclear medicine and biology},
  year={2015},
  volume={42 12},
  pages={975-81}
}
INTRODUCTION Phosphodiesterase 7 (PDE7) hydrolyzes selectively cyclic adenosine monophosphate (cAMP) which is an intracellular second messenger. PDE7 is expressed by 2 genes which are both present in the brain. To date there is no radiotracer for PDE7 imaging described and detection of PDE7 has only been performed by ex vivo techniques. In this report we… CONTINUE READING