Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams

  title={Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams},
  author={Aldo Andreani and Alessandra Locatelli and Alberto Leoni and Rita Morigi and Michele Chiericozzi and A Fraccari and Iraklis Galatulas and Giofr{\`e} Salvatore},
  journal={European Journal of Medicinal Chemistry},

Imidazo[2,1 -b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition.

(2-chloroindolyl)methylene-2-indolinone is identified as a new lead of a class of CDK1/cyclinB inhibitors, whose potency can be improved by the introduction of suitable variations on the basic molecular skeleton.

Antitumor activity of bis-indole derivatives.

It is demonstrated that this approach to synthesis of compounds formed by two indole systems separated by a heterocycle was successful, since some of the compounds described are much more active than the numerous, so far prepared and tested 3-indolylmethylene-2-indolinones.

Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

The ability of these derivatives to inhibit cellular proliferation was accompanied by increased level of p53 and its transcriptional targets p21 and Bax, interference in the cell cycle progression with cell accumulation in the G2/M phase, and activation of apoptosis.

Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines.

Preparation of unsubstituted dipyridine‐dibarbituric acid ylide through dimerization of pyridin‐2‐ylmethylenepyrimidinetrione as a reactive intermediate

Preparation of 5,5′-(pyridin-2-ylmethylene)dipyrimidinetrione from barbituric acid and 2-pyridinecarbox-aldehyde in any polar solvent is a straightforward synthetic procedure, while preparation of

Microwave‐Assisted Solvent‐Free Regiospecific Synthesis of 5‐Alkylidene and 5‐Arylidenehydantoins

Abstract Hydantoins have become a well‐known class of structures that have found significant applications as agrochemicals and therapeutics. This structural motif is of interest in the synthesis of



Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.

The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of

Nonsteroidal antiinflammatory agents. 2. Synthesis and biological activity of 2-chloroindolecarboxylic acids.

The Vilsmeier and the Arndt-Eistert reactions have been employed for the synthesis of 1-phenyl-2-chloroindole-3-acetic acid, which was compared with the activity of indomethacin in the carrageenin rat edema.

Kondensierte Indole aus 2‐Chlorindolaldehyd‐(3)

Aus 2‐Oxindolen lassen sich mit dem Vilsmeier‐Reagens 2‐Chlorindol‐3‐aldehyde darstellen, während 2– bzw. 3‐Pyrrolone zu 2– bzw. 3‐Hydroxypyrrolaldehyden führen. Unter gleichen Bedingungen reagieren