Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones

@article{Andreani1997SynthesisAP,
  title={Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones},
  author={Aldo Andreani and Alessandra Locatelli and Alberto Leoni and Mirella Rambaldi and Rita Morigi and Rosaria Bossa and Michele Chiericozzi and A Fraccari and Iraklis Galatulas},
  journal={European Journal of Medicinal Chemistry},
  year={1997},
  volume={32},
  pages={919-924}
}

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TLDR
(2-chloroindolyl)methylene-2-indolinone is identified as a new lead of a class of CDK1/cyclinB inhibitors, whose potency can be improved by the introduction of suitable variations on the basic molecular skeleton.

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Treatment with these three compounds resulted in accumulation of cells in G2/M phase, inhibition of tubulin assembly, and increased cyclin‐B1 protein levels, as well as potent anti‐proliferative activity.

Studies With 2-Benzothiazolylacetonitrile: Synthesis of New 2-Thienylbenzothiazoles and N-Thienyl maleimide Derivatives

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Bioactivity-guided mixed synthesis and evaluation of α-alkenyl-γ and δ-lactone derivatives as potential fungicidal agents

TLDR
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