• Chemistry, Medicine
  • Published in Acta pharmaceutica 2004

Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.

@article{Wujec2004SynthesisAP,
  title={Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.},
  author={Monika Wujec and Monika Pitucha and Maria Dobosz and Urszula Kosikowska and Anna Malm},
  journal={Acta pharmaceutica},
  year={2004},
  volume={54 3},
  pages={
          251-60
        }
}
In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene- 2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity. 

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References

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SHOWING 1-7 OF 7 REFERENCES

Synthesis of some new 1 - acyl - thiosemicarbazides , 1 , 3 , 4 - oxadiazoles , 1 , 3 , 4 - thiadiazoles and 1 , 2 , 4 - triazole - 3 - thiones and their anti - inflamatory activities

A. A. Bahajaj Eweiss
  • Arzneim . Forsch .
  • 2001

Synthesis and properties of 5 - ( 4 , 6 - diphenyl - 2 - pyrimidin - 2 - yl ) - 1 , 2 , 4 - triazoline - 5 - thione and its derivatives

E. Palaska Sahin, P. Kelicen, R. Demirdamar, G. Altmok
  • Pharmazie
  • 1998

Synthesis of new thiourea derivatives of  2 - 1 , 2 , 4 - triazoline - 5 - thione and 1 , 3 , 4 - thiadiazole

Dobosz, A. Pachuta-Stec
  • Acta Polon . Pharm .
  • 1994

Synthesis and antimicrobial activity of some 4 - amino - 5 - aryl - 1 , 2 , 4 - triazole - 3 - thiones and their derivatives

F. Bonina Mazzone, R. Arrigo Reina
  • J . Heterocycl . Chem .
  • 1986

Dobosz , Studies on products of transformations of 4 - carbethoxymethyl - 1 , 2 , 4 - triazoline - thiones

P. Gaidelis Mekuskiene, P. Vainilavicius
  • Acta Polon . Pharm .
  • 1984

Synthesis of trans - 1 , 2 - bis ( 2R - amino - 1 , 3 , 4 - thiadiazol - 5 - yl ) ethene and trans - 1 , 2 - bis  3 - ( 4 - substituted -  2 - 1 , 2 , 4 - triazoline - 5 - thione )  ethane

M. Wujec Dobosz
  • Synthesis of 3 - amino - 1 , 2 , 4 - triazole derivatives , Ann . UMCS , Lublin , Sectio AA
  • 1963

The reaction of cyclization of thiosemicarbazide derivatives to 1 , 2 , 4 - triazole or 1 , 3 , 4 - thiadiazole system

M. Pitucha Dobosz, M. Wujec
  • Synthesis of thiosemicarbazide derivatives with 1 , 2 , 4 - tria - zole system , Ann . UMCS , Lublin , Sectio AA