Synthesis and physicochemical, in vitro and in vivo evaluation of an anisotropic, nanocrystalline hydroxyapatite bisque scaffold with parallel-aligned pores mimicking the microstructure of cortical bone.

@article{Despang2015SynthesisAP,
  title={Synthesis and physicochemical, in vitro and in vivo evaluation of an anisotropic, nanocrystalline hydroxyapatite bisque scaffold with parallel-aligned pores mimicking the microstructure of cortical bone.},
  author={Florian Despang and Anne Bernhardt and Anja Lode and R. Dittrich and Thomas Hanke and Sachin J. Shenoy and Susan Mani and Annie John and Michael Gelinsky},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2015},
  volume={9 12},
  pages={
          E152-66
        }
}
Scaffolds for bone regeneration are mostly prepared with an isotropic, sponge-like structure mimicking the architecture of trabecular bone. We have developed an anisotropic bioceramic with parallel aligned pores resembling the honeycomb arrangement of Haversian canals of cortical bone and investigated its potential as a scaffold for tissue engineering. Parallel channel-like pores were generated by ionotropic gelation of an alginate-hydroxyapatite (HA) slurry, followed by ceramic processing… CONTINUE READING

Citations

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SHOWING 1-10 OF 10 CITATIONS

Bioinspired scaffolds for osteochondral regeneration.

  • Tissue engineering. Part A
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

The role of mesenchymal stem cells in maintenance and repair of bone

R Bielby, E Jones, D. McGonagle
  • Injury 38(suppl
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Biomorphous porous hydroxyapatite-ceramics from rattan (Calamus Rotang)

  • Journal of materials science. Materials in medicine
  • 2010
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

High-solid-content hydroxyapatite slurry for the production of bone substitute scaffolds.

  • Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
  • 2009
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL