Synthesis and photobiological study of a novel chlorin photosensitizer BCPD-18MA for photodynamic therapy.

  title={Synthesis and photobiological study of a novel chlorin photosensitizer BCPD-18MA for photodynamic therapy.},
  author={Jialiang Zhang and Li Deng and Jianzhong Yao and Peng Gu and Feng Yang and Xiu Yun Wang and Wei Liu and Yingying Zhang and Xingfa Ke and Xiaolong Jing and Jianming Chen},
  journal={Bioorganic \& medicinal chemistry},
  volume={19 18},

Chlorin p6-Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy.

Aspartylchlorin p6 dimethylester (7b) represents a promising photosensitizer for PDT applications because of its strong absorption in the phototherapeutic window, relatively high singlet oxygen quantum yield, highest dark toxicity/phototoxicity ratio, good water solubility, and excellent in vivo PDT antitumor efficacy.

Benzochloroporphyrin derivative photosensitizer-mediated photodynamic therapy for Ewing sarcoma.

Antitumor effect of photodynamic therapy with a novel targeted photosensitizer on cervical carcinoma.

The results suggested that apoptosis was the primary mode of HeLa cell death induced by Ps I-PDT and has potential as an alternative treatment modality for cervical cancer.

Synthesis and in vitro phototoxicity of novel π-extension derivatives of chlorin e6

The enhanced cellular uptake and reactive oxygen species (ROS) production of modified chlorins were found to be responsible for their increased in vitro phototoxicity.



Verteporfin-photoinduced apoptosis in HepG2 cells mediated by reactive oxygen and nitrogen species intermediates

It is suggested that these events serve as the final arbitrator to initiate the lethal apoptotic process of HepG2 cells under PDE, and the data are consistent with the notion that GSH depletion is an effective strategy to sensitize cancer cells to undergo apoptosis.

In Vitro Photodynamic Therapy with Chlorin e6 Leads to Apoptosis of Human Vascular Smooth Muscle Cells

The results obtained with human VSMCs show that chlorin e6 may be useful in the PDT of aerial restenosis, but its efficacy still needs to be established in an animal model.

Apoptosis following photodynamic tumor therapy: induction, mechanisms and detection.

The (experimental) variables determining the cellular response after PDT and the known mechanistic details of PDT-triggered induction and execution of apoptosis are discussed, accompanied by a critical evaluation of wide-spread methods employed in apoptosis detection with special respect to in vitro/cell-based methodology.

Involvement of both caspase-dependent and -independent pathways in apoptotic induction by hexaminolevulinate-mediated photodynamic therapy in human lymphoma cells

It is demonstrated that cytochrome c-mediated caspase-dependent pathway and AIF-induced casp enzyme-independent pathway are simultaneously involved in the apoptotic induction by PDT.

Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy.

Liposomal delivery of photosensitising agents

Progress in the use of liposomal photosensitisers is covered, currentliposomal formulations are summarised, and future directions for the liposome delivery of photosensitising agents are project.