Synthesis and pharmacological properties of some 7H-[1] benzothiopyrano-[3,2-c] quinolin-7-ones.

Abstract

The title compounds 3a-d were prepared by intramolecular cyclization of 2-[S-(quinolyl-4)]-thiobenzoic acids 2a-d. The effects of 3a-d on the central nervous system were tested. Among the investigated benzothiopyranoquinolinones, the 2-chloro-6-methyl-derivative (3c) showed analgesic activity in the hot-plate and the writhing tests in doses over 100 mg/kg… (More)

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