Synthesis and pharmacological properties of some 2-pyrrolidinone Mannich bases.


N-aminoalkyl derivatives of 2-pyrrolidinone (1-5) and methylene-bis-amino derivatives (7-9) as intermediary products formed during aminoalkylation were described. Compounds 2 and 3, in doses over 30 and 20 mg/kg resp., displayed analgesic properties; compound 3 exerted also a weak anti-inflammatory action (37 mg/kg po) in the carrageenin test. 


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