Synthesis and pharmacological properties of 1,2,3-substituted 1,2,3,4-tetrahydro-β-carbolines

@article{Pogosyan2004SynthesisAP,
  title={Synthesis and pharmacological properties of 1,2,3-substituted 1,2,3,4-tetrahydro-β-carbolines},
  author={S. A. Pogosyan and L. A. Matevosyan and A. S. Melik-Ogandzhanyan and R. R. Safrazbekyan and E. M. Arzanunts and I. S. Sarkisyan and R. G. Paronikyan and N. E. Akopyan},
  journal={Pharmaceutical Chemistry Journal},
  year={2004},
  volume={20},
  pages={714-717}
}
The condensation of I with aldehyde II was carried out by heating equimolar amounts of the components in boiling water in the presence of 2 N H=SO,. The structure of 8-carboline III was confirmed by IR and PMR spectra, and also by the negative Ehrlich color reaction, indicating the absence of a free 2-position in the indole ring. In the IR spectrum there is… CONTINUE READING