Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists.


A new series of 9-deazaxanthine derivatives with various substituents at the heterocyclic system were synthesized and evaluated for their binding affinities for the four human recombinant adenosine receptors, A(1)-A(3) subtypes. A number of the 9-deazaxanthines derivatives 3a-m showed moderate-to-high affinity for hA(2B) receptors, with compound 3f showing… (More)
DOI: 10.1016/j.ejmech.2010.03.011


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