Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.

@article{Shao2011SynthesisAP,
  title={Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.},
  author={L. Shao and Fengjiang Wang and S. Malcolm and J. Ma and M. Hewitt and U. Campbell and Larry R Bush and Nancy A Spicer and S. Engel and L. D. Saraswat and L. Hardy and P. Koch and R. Schreiber and K. Spear and M. Varney},
  journal={Bioorganic \& medicinal chemistry},
  year={2011},
  volume={19 1},
  pages={
          663-76
        }
}
The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activity. The detailed synthesis and in vitro activity and ADME profile of compounds is described, which represent a previously undisclosed triple reuptake inhibitor chemotype. 
Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentre.
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