Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.

@article{Guerrero2007SynthesisAP,
  title={Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.},
  author={Mar{\'i}a Dolores Guerrero and Maurizio Aquino and Ines Bruno and Mar{\'i}a del Carmen Terencio and Miguel Pay{\'a} and Raffaele Riccio and Luigi Gomez-Paloma},
  journal={Journal of medicinal chemistry},
  year={2007},
  volume={50 9},
  pages={2176-84}
}
As a part of our drug discovery effort, recently we clarified the molecular basis of phospholipase A2 (PLA2) inactivation by petrosaspongiolide M (PM), an interesting metabolite belonging to a marine sesterterpene family, containing in its structural architecture a gamma-hydroxybutenolide moiety and showing potent anti-inflammatory activity. In the attempt… CONTINUE READING