Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: quantitative structure-activity relationships.

@article{Chiaradia2008SynthesisAP,
  title={Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: quantitative structure-activity relationships.},
  author={Louise Domeneghini Chiaradia and Rodrigo Pires dos Santos and Carlos Eduardo Vitor and Andr{\'e} Alexandre Vieira and Paulo Cesar dos Santos Leal and Ricardo Jos{\'e} Nunes and Jo{\~a}o Batista Calixto and Rosendo Augusto Yunes},
  journal={Bioorganic & medicinal chemistry},
  year={2008},
  volume={16 2},
  pages={658-67}
}
Inhibition of nitric oxide (NO) production by altering the expression of induced enzymes involved is potentially an important strategy for obtaining antiinflammatory agents. In the search for hits to obtain lead compounds for new drugs of this class, 14 synthetic chalcones derived from 2,4,6-trimethoxyacetophenone were evaluated in terms of their inhibitory action, in vitro, in relation to NO production in murine macrophages of the line RAW 264.7 induced by bacterial lipopolysaccharides (LPS… CONTINUE READING

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