Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: quantitative structure-activity relationships.

@article{Chiaradia2008SynthesisAP,
  title={Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: quantitative structure-activity relationships.},
  author={Louise Domeneghini Chiaradia and Rodrigo dos Santos and Carlos Eduardo Vitor and Andr{\'e} Alexandre Vieira and Paulo C{\'e}sar Leal and Ricardo J Nunes and Jo{\~a}o B. Calixto and Rosendo Augusto Yunes},
  journal={Bioorganic \& medicinal chemistry},
  year={2008},
  volume={16 2},
  pages={
          658-67
        }
}
Investigating the potential of tetrahydropyridinyl chalcones as useful agents against breast carcinoma: An in vitro and in vivo study
N-Benzyltetrahydropyridinyl-4,6-dimethoxy phenyl-substituted 2′-hydroxychalcones SJC1–15 were synthesized using Claisen–Schmidt condensation, their structures confirmed by spectral analysis, and
CHALCONE AS A VERSATILE MOIETY FOR DIVERSE PHARMACOLOGICAL ACTIVITIES
Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific
Nitric oxide inhibitory activity of hydrogenated synthetic analogues of furanonaphthoquinones isolated from Tabebuia spp.
TLDR
The results indicated that FNQ5 might be considered as useful potential anti-inflammatory molecule to treat inflammatory diseases related with nitric oxide overproduction.
Synthesis, structure-activity relationships, and biological studies of chromenochalcones as potential antileishmanial agents.
TLDR
Pharmacokinetics and serum albumin binding studies suggest that compound 16 has the potential to be a candidate for the treatment of the nonhealing form of leishmaniasis.
Synthesis and QSAR analysis of chalcone derivatives as nitric oxide inhibitory agent
In this study, thirty-eight chalcone analogs were synthesized and evaluated for nitric oxide (NO) inhibition activity on RAW 264.7 cells. Among these compounds, chalcones bearing furanyl group showed
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A series of 2'-substituted chalcone derivatives has been found to show potent inhibition of the production of IL-1 beta from human peripheral blood monocytes stimulated with lipopolysaccharide, suggesting a degree of selectivity which would not be expected for simple, nonspecific alkylating agents.
Studies on the chemical constituents of stem bark of Millettia leucantha: isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities.
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Interestingly, flavone 8 showed significant anti-inflammatory effects inhibiting both cyclooxygenase (COX)-1 and -2, and moderate cytotoxic activity was observed in chalcones, whereas dihydrochalcones showed moderate anti-Herpes Simplex Virus (HSV) activity.
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Antimalarial Alkoxylated and Hydroxylated Chalones: Structure−Activity Relationship Analysis
Chalcones with 2‘,3‘,4‘-trimethoxy, 2‘,4‘-dimethoxy, 4‘-methoxy, 4‘-ethoxy, 2‘,4‘-dihydroxy, and 4‘-hydroxy groups on ring B were synthesized and evaluated in vitro against Plasmodium falciparum (K1)
Antifungal Activity and Studies on Mode of Action of Novel Xanthoxyline‐Derived Chalcones
TLDR
Results indicate that neither the sole presence of a “xanthoxyline‐like” substitution pattern nor a 2′‐OH substituent on ring A are sufficient for these compounds to have antifungal properties.
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