Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.

@article{Shukla2010SynthesisAO,
  title={Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.},
  author={Shreya Shukla and Rekha J. Nair and Marsha W. Rolle and Kathleen R. Braun and Christina K. H. Chan and Pamela Y. Johnson and Thomas N Wight and Todd C. McDevitt},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2010},
  volume={58 4},
  pages={345-58}
}
Embryonic stem cells (ESCs) provide a convenient model to probe the molecular and cellular dynamics of developmental cell morphogenesis. ESC differentiation in vitro via embryoid bodies (EBs) recapitulates many aspects of early stages of development, including the epithelial-mesenchymal transition (EMT) of pluripotent cells into more differentiated progeny. Hyaluronan and versican are important extracellular mediators of EMT processes, yet the temporal expression and spatial distribution of… CONTINUE READING

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