Synthesis and molecular structure of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17β-yl)-3-hydroxypropylamine; an amino-estrogen with prolonged anticoagulant and brief estrogenic effects

@article{Fernndezg1985SynthesisAM,
  title={Synthesis and molecular structure of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17$\beta$-yl)-3-hydroxypropylamine; an amino-estrogen with prolonged anticoagulant and brief estrogenic effects},
  author={J. M. Fern{\'a}ndez-g and M. Rubio-Arroyo and M. Soriano-garcia and R. Toscano and M. C. P{\'e}rez-C{\'e}sar and C. Rubio-P{\'o}o and J. Mandoki and A. Pe{\~n}a and C. Lemini and N. Mendoza-Pati{\~n}o and F. Cruz},
  journal={Steroids},
  year={1985},
  volume={45},
  pages={151-157}
}
The synthesis and molecular structure of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-3-hydroxypropylamine, is described. It was characterized by ir, nmr, mass spectrometry and chemical analysis. The crystal structure of this compound was determined by single-crystal x-ray diffraction. Prolame belongs to space group P212121. Cell dimensions are: a = 8.356(2), b = 13.343(4) and c = 16.119(4) A. Z = 4; R = 4.1%. 
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