Synthesis and mechanisms of decomposition of some cephalosporin prodrugs.

  title={Synthesis and mechanisms of decomposition of some cephalosporin prodrugs.},
  author={Andr{\'e}s Saab and Anwar A. Hussain and Indravadan H. Patel and Lewis W. Dittert},
  journal={Journal of pharmaceutical sciences},
  volume={79 9},
The delta-3 and delta-2 methyl esters of cefazolin were synthesized. The kinetics and mechanisms of degradation of the methyl esters and the delta-3 and delta-2 isomers of pivaloyloxymethyl prodrug esters of the new cephalosporin ceftetrame (Ro 19-5247) were investigated in buffer systems and in human plasma in vitro. The major hydrolytic products of all the delta-3 and delta-2 esters were the inactive delta-2 cephalosporin free acids. The following reaction scheme describes the in vitro… CONTINUE READING
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