Synthesis and investigations on the oxidative degradation of C3/C5-alkyl-1,2,4-triarylpyrroles as ligands for the estrogen receptor.

Abstract

In this study, we synthesized 1,2,4-triarylpyrroles as ligands for the estrogen receptor (ER). Two pyrrole series were prepared with either C3-alkyl or C3/C5-dialkyl residues. Compounds from both series were susceptible to oxidative degradation-dialkylated compounds (t(1/2) =33-66 h) to a higher extent than their monoalkylated congeners (t(1/2) =140-211 h… (More)
DOI: 10.1002/cmdc.201000537

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@article{Schfer2011SynthesisAI, title={Synthesis and investigations on the oxidative degradation of C3/C5-alkyl-1,2,4-triarylpyrroles as ligands for the estrogen receptor.}, author={Anja Sch{\"a}fer and Anja Wellner and Ronald Gust}, journal={ChemMedChem}, year={2011}, volume={6 5}, pages={794-803} }