Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.

@article{Shoman2009SynthesisAI,
  title={Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.},
  author={Mai E. Shoman and M. Yaser Abdel-Aziz and Omar A. M. Aly and Hassan H. Farag and Mohamed Abdelhamed Morsy},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 7},
  pages={3068-76}
}
A group of 3,5-diaryl-2-pyrazoline derivatives were prepared via the reaction of various chalcones with hydrazine hydrate in ethanol. A group of NO-donating-2-pyrazoline derivatives were synthesized by carrying a nitrate ester group or an oxime group onto the prepared pyrazoline derivatives through different spacers. The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced rat paw edema and compared to a well-known NSAID, indomethacin as a reference… CONTINUE READING

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Chalcones as Versatile Synthons for the Synthesis of 5-and 6-membered Nitrogen Heterocycles

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