Synthesis and in vivo evaluation of [11C]SA6298 as a PET sigma1 receptor ligand.

@article{Kawamura1999SynthesisAI,
  title={Synthesis and in vivo evaluation of [11C]SA6298 as a PET sigma1 receptor ligand.},
  author={Kazunori Kawamura and Kiichi Ishiwata and Hisashi Tajima and Shin-ichi Ishii and Yuhei Shimada and Kiyoshi Matsuno and Yoshio Homma and Michio Senda},
  journal={Nuclear medicine and biology},
  year={1999},
  volume={26 8},
  pages={
          915-22
        }
}
Preclinical evaluation of [11C]SA4503: radiation dosimetry,in vivo selectivity and PET imaging of sigma1 receptors in the cat brain
TLDR
The present study characterized this ligand and concluded that [11C]SA4503 has the potential for mapping sigma1 receptor by PET.
Evaluation of [11C]SA5845 and [11C]SA4503 for imaging of sigma receptors in tumors by animal PET
TLDR
Two sigma receptor ligands may be potential ligands for PET imaging of sigma receptors-rich tumors, evaluation of SA5845 and SA4503 in rats and rabbits.
Novel 99m Tc labeled σ receptor ligand as a potential tumor imaging agent
A novel 99mTc labeled complex, [N-[2-((2-oxo-2-(4-(3-phenylpropyl)piperazin-1-yl)ethyl) (2-mercaptoethyl)amino)acetyl]-2-aminoethanethiolato]Technetium(V) oxide (PPPE-MAMA’-99mTcO) ([99mTc]-2) has
Different brain kinetics of two sigma1 receptor ligands, [3H](+)‐pentazocine and [11C]SA4503, by P‐glycoprotein modulation
TLDR
It is concluded that the P‐glycoprotein modulation resulted in the different brain kinetics of the two radioligands, which is suitable as an in vivo probe, but radiolabeled (+)‐pentazocine is not.
In vitro and in vivo evaluation of [125/123I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol([125/123I]-OI5V) as a potential sigma-1 receptor ligand for SPECT
We investigated the characteristics of radio-iodinated 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) as a single photon emission computed tomography (SPECT) ligand for mapping sigma-1 receptor
Evaluation of spirocyclic 3-(3-fluoropropyl)-2-benzofurans as sigma1 receptor ligands for neuroimaging with positron emission tomography.
TLDR
A series of various N-substituted 3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4'-piperidines] (7) has been synthesized and significant reduction in the uptake of radioactivity was observed in the brain and peripheral organs expressing sigma(1) receptors.
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References

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Synthesis and in vivo evaluation of [11C]semotiadil, a benzothiazine calcium antagonist.
Synthesis of [18F]-1-(3-fluoropropyl)-4-(4-cyanophenoxymethyl)-piperidine : A potential sigma-1 receptor radioligand for PET
[ 18 F]-1-(3-Fluoropropyl)-4-(4-cyanophenoxymethyl)piperidine has been prepared as a potential sigma-1 receptor ligand for PET. The unlabeled ligand was found to be selective in vitro for the sigma-1
Synthesis of a selective sigma receptor radioligand for SPECT : [123I]-1-(2-hydroxyethyl)-4-(4-iodophenoxymethyl)piperidine
[ 123 I]-1-(2-Hydroxyethyl)-4-(4-iodophenoxymethyl)piperidine has been prepared as a novel sigma receptor radioligand for tumour imaging by SPECT. This ligand was found to be selective in vitro for
Synthesis and PET studies of fluorine-18-BMY 14802: a potential antipsychotic drug.
TLDR
The lack of regional distribution consistent with the known distribution of sigma binding sites as well as the lack of stereoselectivity suggest that the behavior of BMY 14802 in the brain is dominated by its transport properties in tissue rather than its binding to sigma sites.
Synthesis and Pharmacological Characterization of 4-[125I]-N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide: A High Affinity σ Receptor Ligand for Potential Imaging of Breast Cancer
TLDR
Results demonstrate that a high density of a receptors are expressed in MCF-7 ceils and that radioiodinated 4-1HI' may be useful for imaging breast cancer by targeting <rsites.
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