Synthesis and in vitro photodynamic therapy of chlorin derivative 131-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a.

@article{Cheng2017SynthesisAI,
  title={Synthesis and in vitro photodynamic therapy of chlorin derivative 131-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a.},
  author={Jianjun Cheng and Wenting Li and Guanghui Tan and Zhiqiang Wang and Shuai Li and Yingxue Jin},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2017},
  volume={87},
  pages={
          263-273
        }
}
Photodynamic therapy (PDT) is entering the mainstream of the cancer treatments recently. Pyropheophorbide-a (Pa), as a degradation product of chlorophyll-a, has been shown to be a potent photosensitizer in photodynamic therapy. In this paper, we investigated the in vitro photodynamic therapy of 131-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a (PHPa) against human HeLa cervical cancer cell line, together with ultraviolet-visible spectra, fluorescence emission spectra… CONTINUE READING
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