Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues.

Abstract

Salvinorin A is the most potent naturally occurring opioid agonist yet discovered with high selectivity and affinity for kappa-opioid receptor. To explore its structure and activity relationships, a series of salvinorin A derivatives modified at the C2 position were prepared and studied. These salvinorin A derivatives were screened for binding and… (More)

Topics

1 Figure or Table

Cite this paper

@article{Lee2005SynthesisAI, title={Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues.}, author={David Y.W. Lee and Vishnu Vardhan Reddy Karnati and Minsheng He and Lee-Yuan Liu-Chen and Leelakrishna Kondaveti and Zhongze Ma and Yulin Wang and Yong Zhou Chen and C{\'e}cile B{\'e}guin and William A. Carlezon and Bruce M. Cohen}, journal={Bioorganic & medicinal chemistry letters}, year={2005}, volume={15 16}, pages={3744-7} }