Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.


A series of analogues were synthesized by optimizing the structure of papaverine. The in vitro PDE10A binding affinity (IC(50)) values for these new analogues were measured; for compounds that have IC(50) value less than 60 nM for PDE10A, the binding affinities (IC(50) value) for PDE3A and PDE3B were tested. Of these analogues, compounds 6a, 6b, 6n, 8b, 8c… (More)
DOI: 10.1016/j.ejmech.2011.05.072


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