Synthesis and in vitro cytotoxic activity of new N-diazoacetylglycine derivatives

Abstract

The syntheses of various N-diazoacetylglycine derivatives are described. The results of an in vitro screening carried out on KB cells for cytotoxic activity are reported. The most active compounds are DGE, DGiBA and DGHA. A possible relationship between the activity and the liposolubility of these compounds is discussed. 
DOI: 10.1007/BF01990207

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