Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.

@article{Kim2008SynthesisAI,
  title={Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.},
  author={Hyojung Kim and Bora Kim and Hyuk Mun Kim and Soojong Um and Joodong Lee and Heechang Ryoo and Hyungil Jung},
  journal={Bioorganic & medicinal chemistry},
  year={2008},
  volume={16 12},
  pages={6387-93}
}
A new hybrid, retinyl retinoate 1, was synthesized with a condensing reaction between retinol and retinoic acid to improve the photo-stability, and the in vitro biological activity of the hybrid was analyzed. This retinol derivative had enhanced thermal stability and decreased photosensitivity, and exhibited decreased cell toxicity compared to that of… CONTINUE READING