Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters.

@article{Nda2011SynthesisAI,
  title={Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters.},
  author={David D N'da and Jaco C. Breytenbach and Peter J. Smith and Carmen A Lategan},
  journal={Arzneimittel-Forschung},
  year={2011},
  volume={61 6},
  pages={358-65}
}
New 4-aminoquinoline-derived esters containing the redox-active ferrocene group brought in by either ferrocenyformic or 4-ferrocenylbutanoic acids were synthesized and tested in vitro for their antiplasmodial activity. The results revealed that only esters derived from ferrocenylformic acid were active against both chloroquine (CQ)-resistant Dd2 and CQ-sensitive D10 strains of Plasmodium falciparum. However, none of these showed higher actvity than CQ against the sensitive strain. Ester 16… CONTINUE READING