Synthesis and in-vitro activity of novel 1beta-methylcarbapenems having spiro[2,4]heptane moieties.

@article{Park2007SynthesisAI,
  title={Synthesis and in-vitro activity of novel 1beta-methylcarbapenems having spiro[2,4]heptane moieties.},
  author={Hyeong Beom Park and Nam H. Jo and Joon Hee Hong and Jung Hoon Choi and Jung-Hyuck Cho and Kyung Ho Yoo and Chang-Hyun Oh},
  journal={Archiv der Pharmazie},
  year={2007},
  volume={340 10},
  pages={
          530-7
        }
}
The synthesis of a new series of 1beta-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in-vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Most compounds were shown to be more active than the compared meropenem and imipenem against Escherichia coli. One particular compound, IIIb, having hydroxy a moiety showed the most potent antibacterial activity.